Drs. Dawn Bowers and Adam Woods at UF and Dr. Gene Alexander at the University of Arizona were awarded a $3.8 million grant from the NIH/NIA to learn whether a novel, low cost intervention may improve cognition, mood, and brain function in older adults at risk for developing Alzheimer’s disease. Called the Revitalize study, the intervention involves transcranial and intranasal delivery of low level light (near infrared) over a 12 week period. This is a blinded sham-controlled RCT targeting cognitive, mood, and neuroimaging outcomes (MRS Spectroscopy, resting state fMRI). Participants with subjective cognitive decline and a family history of Alzheimer’s disease will be run across both sites. The presumed mechanism of change underlying photobiomodulation, based on animal studies, is improved mitochondrial function via ATP and increased blood flow.
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